Innovative Technology Activating Natural Pain Relief Mechanisms via Arm-to-Brain Stimulation
The human brain can naturally turn off pain through a mechanism called conditioned pain modulation (CPM). When CPM is activated, the body releases powerful signals (neurotransmitters) to reduce or eliminate pain. There is scientific evidence that people with migraine may have an impaired or lower CPM response, so Nerivio uses non-painful Remote Electrical Neuromodulation (REN) to trigger peripheral nerves and activate the CPM.
In simpler terms, stimulating the upper arm triggers a natural process in the brain that controls migraine pain and other related symptoms, providing essential relief.
The Nerivio REN wearable in action
Nerivio stimulates nociceptive nerve fibers (types A-delta and C) in the upper arm.
Stimulation of these nerve fibers sends messages to the pain regulation centers in the brainstem
This triggers the body’s Conditioned Pain Modulation (CPM) system, activating the descending pain inhibitory pathways
Descending inhibitory signals travel to the trigeminal cervical complex where serotonin and norepinephrine (powerful neurotransmitters) are released
The release of these neurotransmitters leads to relief from migraine and migraine-related symptoms.
Nerivio’s activation of the body’s endogenous (natural) analgesic system has a global impact on pain.
Nerivio Is Not a TENS Unit
The Nerivio REN wearable and TENS units use different mechanisms of action, based on different electrical pulses and different stimulation sites.
The Nerivio uses a Remote Electrical Neuromodulation (REN) mechanism to work with the body and not against it. Nerivio works from a remote location to the source of pain, activating the Conditioned Pain Modulation mechanism, leading to migraine relief.
TENS units stimulate local nerves and compete with local sensory nerve fibers to block them from working (a mechanism termed gate theory of pain). TENS must be applied at the same location of the pain (i.e., the head, during a migraine attack).
Features
Nerivio
Remote Electrical
Neuromodulation
TENS
Transcutaneous Electrical Nerve Stimulation